abstract：:Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation. As a result of the amphiphilic properties of these siderophores it is difficult to study siderophore-mediated uptake of iron, because the a...

journal_title：Journal of inorganic biochemistry

authors： Martinez JS,Butler A

更新日期：2007-11-01 00:00:00

abstract：:Preparation of metal/protein hybrids is growing into important topics in the field of bioinorganic chemistry. X-ray crystal structure analyses of them provide direct information on unique interactions of metal cations or metal cofactors to understand and design enzymatic functions. In this mini review, the authors foc...

journal_title：Journal of inorganic biochemistry

authors： Ueno T,Yokoi N,Abe S,Watanabe Y

更新日期：2007-11-01 00:00:00

abstract：:Selenium in the form of selenocysteine plays an essential role in a number of proteins, but its role in non-enzymatic biochemistry is also important. In this short review we discuss the interactions between inorganic selenium, arsenic and mercury under physiological conditions, especially in the presence of glutathion...

journal_title：Journal of inorganic biochemistry

authors： Prince RC,Gailer J,Gunson DE,Turner RJ,George GN,Pickering IJ

更新日期：2007-11-01 00:00:00

abstract：:An array of poly- and mononuclear complexes of Pt(II) with polypyridyl ligands is reported. The framework complexes [(PtCl(2))(2)(bpp)(2)(micro-PtCl(2))](H(2)O)(2) [bpp=2,3-bis(2-pyridyl)pyrazine], [PtCl(2)(micro-tptz)PtClNCPh]Cl [tptz=2,4,6-tris(2-pyridyl)-1,3,5-triazine], and mononuclear PtCl(2)(NH(2)dpt) [NH(2)dpt=...

journal_title：Journal of inorganic biochemistry

authors： Rubino S,Portanova P,Albanese A,Calvaruso G,Orecchio S,Fontana G,Stocco GC

更新日期：2007-10-01 00:00:00

abstract：:Two macrocycles (1 and 2) are prepared that incorporate pendent groups in macrocycle 3 (3=1-oxa-4,7,10-triazacyclododecane) with the goal of studying the effect of these pendent groups on metal ion complexation, solution chemistry and catalysis. Zn(1) contains a macrocyclic ligand with a pendent acridine group and Zn(...

journal_title：Journal of inorganic biochemistry

authors： Rossiter CS,Mathews RA,Morrow JR

更新日期：2007-06-01 00:00:00

abstract：:The three metal-binding ligands of the archetype Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylase, taurine/alphaKG dioxygenase (TauD), were systematically mutated to examine the effects of various ligand substitutions on enzyme activity and metallocenter properties. His99, coplanar with alphaKG and Fe(II), i...

journal_title：Journal of inorganic biochemistry

authors： Grzyska PK,Müller TA,Campbell MG,Hausinger RP

更新日期：2007-05-01 00:00:00

abstract：:A one-pot strategy was first presented in this paper to synthesize gelatin/hydroxyapatite (HAP) composite microspheres in a water-in-oil (W/O) emulsion. Using gelatin droplets as microreactors and colloid protective medium, needle-like nano-HAP crystals (5 nm x 60-100 nm) in form of clusters were homogeneously and ord...

journal_title：Journal of inorganic biochemistry

authors： Teng S,Chen L,Guo Y,Shi J

更新日期：2007-04-01 00:00:00

abstract：:The reaction of [Mn{SSi(OBu(t))3}2(MeOH)4] with imidazole and its two methyl substituted derivatives leads to different types of heteroleptic manganese(II) thiolate complexes. Reaction with 1-methylimidazole gives the silanethiolate devoid of methanol but with two nitrogen ligands and thus central MnN(2)S(2) core. The...

journal_title：Journal of inorganic biochemistry

authors： Kropidłowska A,Chojnacki J,Becker B

更新日期：2007-04-01 00:00:00

abstract：:The binding of Ru(phen)(2)dppz(2+) (dppz=dipyrido[3,2-a:2',3'-c]phenazine) to DNA was investigated at pH 7.0 and 25 degrees C using stopped-flow and spectrophotometric methods. Equilibrium measurements show that two modes of binding, whose characteristics depend on the polymer to dye ratio (C(P)/C(D)), are operative. ...

journal_title：Journal of inorganic biochemistry

authors： Biver T,Cavazza C,Secco F,Venturini M

更新日期：2007-03-01 00:00:00

abstract：:Although selenium is taken with diet mainly as selenoamino acids, its hypoglycaemic action on hepatic gluconeogenesis has been studied with the use of inorganic selenium derivatives. The aim of the present investigation was to compare relative efficacies of inorganic and organic selenium compounds in reducing glucose ...

journal_title：Journal of inorganic biochemistry

authors： Kiersztan A,Lukasinska I,Baranska A,Lebiedzinska M,Nagalski A,Derlacz RA,Bryla J

更新日期：2007-03-01 00:00:00

abstract：:Fe(III)-salen (N,N-bis(salicylidene)-ethane-1,2-diimine) complexes of simple hydroxamic acids and the MMP (matrix metalloproteinase) inhibitor marimastat have been evaluated as hypoxia activated drug carriers. The aceto- (aha), propion- (pha), benzohydroxamato (bha), and marimastat complexes were prepared and characte...

journal_title：Journal of inorganic biochemistry

authors： Failes TW,Hambley TW

更新日期：2007-03-01 00:00:00

abstract：:In heme peroxidases, a distal His residue plays an essential role in the initial two electron oxidation of resting state enzyme to compound I by hydrogen peroxide. A distal Arg residue assists in this process. The contributions of the charge, H-bonding capacity, size, and mobility of this Arg residue to Coprinus ciner...

journal_title：Journal of inorganic biochemistry

authors： Schiødt CB,Veitch NC,Welinder KG

更新日期：2007-02-01 00:00:00

abstract：:An in vitro and in vivo study of some copper chelating anti-inflammatory agents for alleviation of inflammation associated with rheumatoid arthritis (RA) has been conducted. Two copper chelating agents, N(1)-(2-aminoethyl)-N(2)-(pyridin-2-ylmethyl)ethane-1,2-diamine ([555-N]) and N-(2-(2-aminoethylamino)ethyl)picolina...

journal_title：Journal of inorganic biochemistry

authors： Zvimba JN,Jackson GE

更新日期：2007-01-01 00:00:00

abstract：:Ti-containing alpha-Keggin polyoxometalates (POMs) have been proved with properties of both anti-tumor and anti-HIV (human immunodeficiency virus). The potential anti-SARS (severe acute respiratory syndrome) activity of the POMs [alpha-PTi(2)W(10)O(40)](7-) isomers was investigated in this paper by molecular modeling ...

journal_title：Journal of inorganic biochemistry

authors： Hu D,Shao C,Guan W,Su Z,Sun J

更新日期：2007-01-01 00:00:00

abstract：:Inhibitory effects of gold(III) ions (Au(III)) on ribonuclease A (RNase A) and deoxyribonuclease I (DNase I) were investigated at neutral pH. RNase A was completely inhibited by 3 molar equivalents of Au(III) ions. DNase I was inhibited by 10 molar equivalents of Au(III) ions. Stoichiometric analyses suggest that Au(I...

journal_title：Journal of inorganic biochemistry

authors： Maruyama T,Sonokawa S,Matsushita H,Goto M

更新日期：2007-01-01 00:00:00

abstract：:[Au(dppz)(2)]Cl(3) was synthesized by the reaction of HAuCl(4) in excess of the dypirido[3,2-a: 2,3-c]phenazine (dppz) ligand. This complex was characterized by elemental analysis, fast atom bombardment (FAB) mass, NMR, UV-visible and IR spectroscopies. DNA-gold complex interactions were studied by spectroscopic titra...

journal_title：Journal of inorganic biochemistry

authors： Navarro M,Hernández C,Colmenares I,Hernández P,Fernández M,Sierraalta A,Marchán E

更新日期：2007-01-01 00:00:00

abstract：:Chromomycin A(3) (CHR) and mithramycin (MTR), members of the aureolic acid anticancer antibiotics, supposedly act by inhibiting transcription via reversible association with DNA. The complex(es) with bivalent cation such as Mg(2+) and Zn(2+) is (are) the DNA-binding ligand(s). In this paper, we report a detailed study...

journal_title：Journal of inorganic biochemistry

authors： Devi PG,Pal S,Banerjee R,Dasgupta D

更新日期：2007-01-01 00:00:00

abstract：:The kinetics of the reaction of chloroperoxidase with peroxynitrite was studied under neutral and acidic pH by stopped-flow spectrophotometry. Chloroperoxidase catalyzed peroxynitrite decay with the rate constant, k(c,) increasing with decreasing pH. The values of k(c) obtained at pH 5.1, 6.1 and 7.1 were equal to: (1...

journal_title：Journal of inorganic biochemistry

authors： Gebicka L,Didik J

更新日期：2007-01-01 00:00:00

abstract：:Genome sequencing has recently shown the presence of genes coding for NO-synthase (NOS)-like proteins in bacteria. The roles of these proteins remain unclear. The interactions of a series of l-arginine (l-arg) analogs and iron ligands with two recombinant NOS-like proteins from Staphylococcus aureus (saNOS) and Bacill...

journal_title：Journal of inorganic biochemistry

authors： Salard I,Mercey E,Rekka E,Boucher JL,Nioche P,Mikula I,Martasek P,Raman CS,Mansuy D

更新日期：2006-12-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib is successfully used in the treatment of chronic myeloid leukemia, but the occurrence of resistance phenomena can significantly limit therapeutic impact. Imatinib shows synergistic effects with cisplatin, suggesting that the coadministration of different cytostatics might reestab...

journal_title：Journal of inorganic biochemistry

authors： Ott I,Abraham A,Schumacher P,Shorafa H,Gastl G,Gust R,Kircher B

更新日期：2006-11-01 00:00:00

abstract：:The effects exerted by the new complex cis-dichloro-1,2-propylenediaminetetraacetato ruthenium (III), H[RuCl(2)(PDTA-H(2))] [1, RAP], on DNA and cultured tumor cells (ovarian carcinoma TG cell line) were studied. The comparative study of circular dichroism (CD) spectra obtained from DNA and RAP-DNA system evidences th...

journal_title：Journal of inorganic biochemistry

authors： Vilaplana RA,Delmani F,Manteca C,Torreblanca J,Moreno J,García-Herdugo G,González-Vílchez F

更新日期：2006-11-01 00:00:00

abstract：:The low-molecular weight water-soluble Fe(III) and Mn(III) porphyrins--in biologically relevant phosphate-buffered saline medium with ascorbic acid as a source of electrons, under aerobic conditions but without co-oxidant - catalyze the hydroxylation of anti-cancer drug cyclophosphamide to active metabolite 4-hydroxyc...

journal_title：Journal of inorganic biochemistry

authors： Spasojević I,Colvin OM,Warshany KR,Batinić-Haberle I

更新日期：2006-11-01 00:00:00

abstract：:The vitamin B(6) derivatives 4-pyridoxic acid (anionic) and the Schiff base N,N'-ethylenebis(pyridoxylideneiminato) react with UO(2)(NO(3))(2) * 6H(2)O to give [UO(2)(beta-pyracinide)(2)(H(2)O)] (beta-pyracin=4-pyridoxic acid) and [UO(2)(Pyr(2)en)DMSO]Cl(2)(Pyr(2)en=N,N'-ethylenebis(pyridoxylideneiminato); DMSO=dimeth...

journal_title：Journal of inorganic biochemistry

authors： Back DF,de Oliveira GM,Lang ES

更新日期：2006-10-01 00:00:00

abstract：:Two new diMn(III) complexes [Mn(2)(III)L(1)(mu-AcO)(mu-MeO)(methanol)(2)]Br (1) and [Mn(2)(III)L(2)(mu-AcO)(mu-MeO)(methanol)(ClO(4))] (2) (L(1)H(3)=1,5-bis(2-hydroxybenzophenylideneamino)pentan-3-ol; L(2)H(3)=1,5-bis(2-hydroxynaphtylideneamino)pentan-3-ol) were synthesized and structurally characterized. Structural s...

journal_title：Journal of inorganic biochemistry

authors： Biava H,Palopoli C,Shova S,De Gaudio M,Daier V,González-Sierra M,Tuchagues JP,Signorella S

更新日期：2006-10-01 00:00:00

abstract：:A laccase from the fungus Trametes villosa (TviL) was investigated in order to elucidate the reaction mechanism of the reduction of dioxygen to water performed by this blue multi-copper oxidase. The ability of TviL to activate dioxygen was studied by stopped-flow experiments and under steady-state conditions. In the s...

journal_title：Journal of inorganic biochemistry

authors： Bukh C,Lund M,Bjerrum MJ

更新日期：2006-09-01 00:00:00

abstract：:The stoichiometry of dioxygen uptake of Co complexes with 4',5'-bis-(5-chloro-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1a), 4',5'-bis(2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1b), 4',5'-bis-(5-methoxy-2-hydroxyphenylmethylideneimino)benzo-12-crown-4 (1c), 4',5'-bis-(5-chloro-2-hydroxyphenylmethyliden...

journal_title：Journal of inorganic biochemistry

authors： Sun B,Chen J,Hu J,Li X

更新日期：2006-08-01 00:00:00

abstract：:Genomics projects have elucidated several genes that encode protein sequences. Subsequently, the advent of the proteomics age has enabled the synthesis and 3D structure determination for these protein sequences. Some of these proteins incorporate metal atoms but it is often not known whether they are metal-binding pro...

journal_title：Journal of inorganic biochemistry

authors： González-Díaz H,Sánchez-González A,González-Díaz Y

更新日期：2006-07-01 00:00:00

abstract：:Quinoline antimalarial drugs such as chloroquine and related compounds are believed to act by targeting ferriprotoporphyrin IX (Fe(III)PPIX) in the form of hematin (H(2)O/HO-Fe(III)PPIX), its mu-oxo dimer ([Fe(III)PPIX](2)O) or crystalline beta-hematin ([Fe(III)PPIX](2)) in the malaria parasite. Fe(III)PPIX is formed ...

journal_title：Journal of inorganic biochemistry

authors： Egan TJ

更新日期：2006-05-01 00:00:00

abstract：:Antibodies against metal chelates may potentially be used in biomedical applications such as targeted imaging and therapy of cancer. Highly specific monoclonal antibodies can be developed, but their binding strength needs to be maximized for them to be of practical use. In general, the half-life for dissociation of an...

journal_title：Journal of inorganic biochemistry

authors： Corneillie TM,Whetstone PA,Meares CF

更新日期：2006-05-01 00:00:00

abstract：:The pathogenic bacteria Helicobacter pylori require nickel as a cofactor of the enzymes urease and hydrogenase. One of the proteins that controls nickel homeostasis in this organism is Helicobacter pylori NikR (HpNikR), a homologue of nickel-dependent transcription factors from other organisms, which regulates the exp...

journal_title：Journal of inorganic biochemistry

authors： Abraham LO,Li Y,Zamble DB

更新日期：2006-05-01 00:00:00

abstract：:The reactive intermediates formed in the catalase-peroxidase from Synechocystis PCC6803 upon reaction with peroxyacetic acid, and in the absence of peroxidase substrates, are the oxoferryl-porphyrin radical and two subsequent protein-based radicals that we have previously assigned to a tyrosyl (Tyr()) and tryptophanyl...

journal_title：Journal of inorganic biochemistry

authors： Jakopitsch C,Obinger C,Un S,Ivancich A

更新日期：2006-05-01 00:00:00

abstract：:The energy diagram for the catalytic cycle of dioxygen evolution in photosystem II has been recomputed using a slightly different model than the one used previously, since the results showed an erroneous trend in the critical region from S(2) to S(3). By replacing the bicarbonate ligand, which was bridging between cal...

journal_title：Journal of inorganic biochemistry

authors： Siegbahn PE,Lundberg M

更新日期：2006-05-01 00:00:00

abstract：:Transition metals, such as Cu(+2), Mn(+2), and Co(+2), have been seen to catalyze the bicarbonate enhanced oxidation of a variety of substrates by H(2)O(2). In several of these cases it has been demonstrated that CO(2), rather than bicarbonate, is the enhancing species. Mechanisms that are in accord with the data invo...

journal_title：Journal of inorganic biochemistry

authors： Liochev SI,Fridovich I

更新日期：2006-04-01 00:00:00

abstract：:The bacterial cytochrome c peroxidases contain an electron-transferring haem c (E) and a peroxidatic haem c (P). Many are isolated in an inactive oxidised state. Reduction of the E haem promotes Ca(2+)-dependent spin state and coordination changes at the P haem rendering it accessible to ligand. Recent crystallographi...

journal_title：Journal of inorganic biochemistry

authors： Pettigrew GW,Echalier A,Pauleta SR

更新日期：2006-04-01 00:00:00

abstract：:Cyclic voltammetry performed at rapid scan rates on cytochrome P450 from Pseudomonas putida (P450CAM) in didodecyldimethylammonium bromide (DDAB) films on graphite electrodes revealed a couple (E) at 830mV (vs Ag/AgCl). E was not significantly observed at scan rates less than 30V/s at room temperature, suggesting that...

journal_title：Journal of inorganic biochemistry

authors： Udit AK,Hill MG,Gray HB

更新日期：2006-04-01 00:00:00

abstract：:Recently, metal complexes of the isomers and analogs of porphyrin have become important model compounds for heme enzymes and proteins. While the chemistry of metalloporphyrins as heme models still attracts attention, the isomers and analogs of porphyrins provide insight into the biological choice of porphine as the ma...

journal_title：Journal of inorganic biochemistry

authors： Harvey JD,Ziegler CJ

更新日期：2006-04-01 00:00:00

abstract：:Al(III) toxicity in living organisms is based on competition with other metal cations. Mg(II) is one of the most affected cations, since the size similarity dominates over the charge identity. The slow ligand exchange rates for Al(III) render the ion useless as a metal ion at the active sites of enzymes and provide a ...

journal_title：Journal of inorganic biochemistry

authors： Rezabal E,Mercero JM,Lopez X,Ugalde JM

更新日期：2006-03-01 00:00:00

abstract：:Novel chiral Ru(II) complexes [Ru(bpy)2L]2+ (bpy = 2,2-bipyridine; L: o-mopip = 2-(2-methoxylphenyl)imidazo[4,5-f][1,10]phenanthroline, p-mopip = 2-(4-methoxylphenyl)imidazo[4,5-f][1,10]phenanthroline) containing -OCH3 at different positions on the phenyl ring have been synthesized and characterized. The DNA-binding a...

journal_title：Journal of inorganic biochemistry

authors： Shi S,Liu J,Li J,Zheng KC,Huang XM,Tan CP,Chen LM,Ji LN

更新日期：2006-03-01 00:00:00

abstract：:The coordination geometry around copper(II) in [Cu(imda)(phen)(H2O)] (1) (H2imda = iminodiacetic acid, phen = 1,10-phenanthroline) is described as distorted octahedral while those in [Cu(imda)(5,6-dmp)] (2) (5,6-dmp = 5,6-dimethyl-1,10-phenanthroline) and [Cu(imda)(dpq)] (3) (dpq = dipyrido-[3,2-d:2',3'-f]-quinoxaline...

journal_title：Journal of inorganic biochemistry

authors： Selvakumar B,Rajendiran V,Uma Maheswari P,Stoeckli-Evans H,Palaniandavar M

更新日期：2006-03-01 00:00:00

abstract：:Many properties of cytochromes and model systems depend on orientations of axial ligands. In this work, we elucidated the role of porphyrin substituents on orientation of axial ligands in model systems of cytochromes. The orientations of axially coordinated imidazoles and pyridines in crystal structures of model syste...

journal_title：Journal of inorganic biochemistry

authors： Rakić AA,Medaković VB,Zarić SD

更新日期：2006-01-01 00:00:00